To provide a nonsteroidal antiinflammatory compound which does not have a side effect which accompanies a compound of prior art, and to provide a novel and improved method for treating inflammatory disease states and disorders, and for treating and/or preventing ophthalmic diseases or disorders.
A nitrogen monoxide group (NO) and/or a nitrogen dioxide group (NO2) are bonded with the nonsteroidal antiinflammatory compound, and the obtained compound has an excellent bioavailability, and an efficacy as an analgesic and antiphlogistic, and has a possibility of forming a gastroenteric damage (ulcer) which is reduced unexpectedly. Moreover, the obtained compound has an unexpected aspect in treating and/or preventing ophthalmic diseases and disorders. The nitrosated and/or nitrosylated nonsteroidal antiinflammatory compounds provide methods for treating, preventing and/or reducing inflammation, pain, and fever; decreasing or reversing the gastrointestinal, renal and other toxicities resulting from the use of nonsteroidal antiinflammatory drugs.
DONG QING
FANG XINQIN
GARVEY DAVID S
MERCER GREGORY J
RICHARDSON STEWART K
SCHROEDER JOSEPH D
WANG TIANSHENG
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto