Title:
ニトロソ化およびニトロシル化タキサン、組成物および使用方法
Document Type and Number:
Japanese Patent JP2004501143
Kind Code:
A
Abstract:
The present invention describes novel nitrosated and/or nitrosylated taxanes, and novel compositions comprising at least one nitrosated and/or nitrosylated taxane, and, optionally, at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The present invention also provides novel compositions comprising at least one taxane and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The compounds and compositions of the present invention can also be bound to a matrix. The present invention also provides methods for treating or preventing cardiovascular diseases and disorders, autoimmune diseases, pathological conditions resulting from abnormal cell proliferation, polycystic kidney disease, inflammatory disease, preserving organs and/or tissues or to inhibit wound contraction, particularly the prophylactic and/or therapeutic treatment of restenosis, by administering nitrosated and/or nitrosylated taxane or parent taxanes in combination with nitric oxide donors that are capable of releasing nitric oxide or indirectly delivering or transferring nitric oxide to targeted sites under physiological conditions.
Inventors:
Gerby David S.
Let's El. Gordon
Lincia-En
Richardson Stewart Kay.
Wong Tian Shen
Let's El. Gordon
Lincia-En
Richardson Stewart Kay.
Wong Tian Shen
Application Number:
JP2002504242A
Publication Date:
January 15, 2004
Filing Date:
June 22, 2001
Export Citation:
Assignee:
Nitromed Incorporated
International Classes:
A61F2/82; A61K31/145; A61K31/15; A61K31/335; A61K31/337; A61K35/14; A61K45/00; A61K45/06; A61K47/30; A61K47/32; A61K47/34; A61K47/48; A61L29/00; A61L31/00; A61P1/04; A61P7/02; A61P7/04; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P11/02; A61P13/12; A61P17/00; A61P17/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/06; A61P35/00; A61P35/02; A61P37/02; A61P41/00; A61P43/00; C07D305/14; C07D409/12; (IPC1-7): C07D305/14; A61K31/145; A61K31/15; A61K31/337; A61K35/14; A61K45/00; A61K47/30; A61K47/32; A61K47/34; A61K47/48; A61L29/00; A61L31/00; A61M29/02; A61P1/04; A61P7/02; A61P7/04; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P9/14; A61P11/00; A61P11/02; A61P13/12; A61P17/00; A61P17/02; A61P25/28; A61P27/02; A61P27/16; A61P29/00; A61P31/06; A61P35/00; A61P35/02; A61P37/02; A61P41/00; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto