Title:
NMR METHODS FOR MONITORING BLOOD CLOT FORMATION
Document Type and Number:
Japanese Patent JP2019039914
Kind Code:
A
Abstract:
To provide a method of monitoring a clotting process.SOLUTION: The invention features a method of monitoring a clotting process by measuring a signal characteristic of the NMR relaxation of water in a sample undergoing clotting to produce NMR relaxation data, and determining from the NMR relaxation data a magnetic resonance parameter of water in the sample characteristic of the clots being formed. The magnetic resonance parameter value is characteristic of functional fibrinogen-associated water molecules in the blood sample. At least one of the two or more separate water populations may be positively correlated with platelet activation, platelet inhibition, clotting time, platelet-associated clot strength, hematocrit, or fibrinogen-associated clot strength. The magnetic resonance parameter values may indicate a low platelet activity, a high platelet activity, a high functional fibrinogen activity, or a low functional fibrinogen activity.SELECTED DRAWING: None
More Like This:
| WO/2014/134672 | NMR SIGNAL EXCITATION AND ACQUISITION METHODS AND SYSTEM |
| WO/2020/137622 | METHOD FOR MEASURING ACID ANHYDRIDE CONTENT |
| JPS61155741 | METHOD OF MAPPING SUBSTANCE CHARACTERISTIC |
Inventors:
THOMAS JAY LOWERY
VYACHESLAV PAPKOV
WALTER W MASSEFSKI
RAHUL DHANDA
EDWARD CHRIS THAYER
VYACHESLAV PAPKOV
WALTER W MASSEFSKI
RAHUL DHANDA
EDWARD CHRIS THAYER
Application Number:
JP2018149867A
Publication Date:
March 14, 2019
Filing Date:
August 09, 2018
Export Citation:
Assignee:
T2 BIOSYSTEMS INC
International Classes:
G01N24/08; G01N33/86; A61M60/117; A61M60/122; A61M60/178; A61M60/216; A61M60/508
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Yumi Naito