Title:
N,N'-DIFLUORINATED DIAZABICYCLOALKANE DERIVATIVE, N-FLUORINATED AZAAZONIABICYCLOALKANE-LEWIS ACID ADDUCT AND USE AS ELECTROPHILIC FLUORINATING AGENT AND METHOD
Document Type and Number:
Japanese Patent JP2693126
Kind Code:
B2
Abstract:
PURPOSE: To provide N,N'-difluorinated diazacycloalkane derivatives represented by a specific formula which are readily obtainable from starting materials commercially available in substantial quantities and useful in the synthesis of pharmacologically active compounds and for fluorinating agents site-selective towards carbanionic substrates or the like.
CONSTITUTION: The objective derivatives are represented by formula I (wherein (n) is 0, 1 or 2; R1-R5 are each 1-6C alkyl, aryl, 1-6C alkyl substituted aryl or aryl substituted 1-6C alkyl; X- is each a counterion and 2X- is a single divalent counterion) and the adducts thereof is represented by formula II (wherein Y is an easily fluorinatable Lewis acid) and include, e.g. 1-fluoro-4- aza-1-azoniabicyclo[2,2,2]octanetrifluoromonoborane tetrafluoro-borate. Further, it is suitable to e.g. react 1,4-diazabicyclo[2,2,2]-octanefluoromonoborane with sodium tetrafluoroborate in HPLC-extra pure acetonitrile at low temperatures.
Inventors:
Ronald Eric Banks
Application Number:
JP32932794A
Publication Date:
December 24, 1997
Filing Date:
December 02, 1994
Export Citation:
Assignee:
Air Products and Chemicals, Inc.
International Classes:
C07B39/00; C07C17/10; C07C25/00; C07C37/62; C07C39/26; C07C43/225; C07D487/08; (IPC1-7): C07D487/08; C07B39/00
Attorney, Agent or Firm:
Takashi Ishida (3 others)
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