PURPOSE: To obtain N,N-disubstd. arylcycloalkylamines having an inhibitory effect on cholesterol biosynthesis and useful for the treatment and prophylaxis of hyperlipidemia, hypercholesterolemia and atherosclerosis.
CONSTITUTION: The N,N-disubstd. arylcycloalkylamines are compds. of formula I [where (n) is 1 or 2; (m) is 0 or 1; A is a single bond, 1-17C alkylene, 2-17C alkenylene or the like; X is carbonyl or sulfonyl; R1 is 1-5C alkyl; R2 is 1-5C alkyl or the like; R3-R5 are each H or alkyl; R6 is H, 1-6C alkyl or the like; and R7 is H, 3-6C cycloalkyl or the like], e.g. trans-N-(4-chlorobenzenesulfonyl)- N-methyl-4-[4-(2-methoxyethyl)methylaminomethylphenyl]-cyclohexylamine. The compds. of the formula I are obtd. by reacting compds. of formula II with compds. of the formula R2-Y (where Y is a reactive releasable group) optionally in the presence of a base in a solvent such as ethanol at 0-100°C. The compds. of the formula I are also useful for the treatment of exuberant dermatosis, exuberant vascular diseases, tumors, gallstone and mycosis.
PIITAA MIYUURAA
EEBERUHARUTO BUOITOUN
RUDORUFU FURUNAUSU
MIHIYAERU MARUKU
BERUNHARUTO AIZERU
RARUFU MIHIYAERU BUTOTSUINSUKI
GERUHARUTO HAARERUMAIERU
