Title:
NN*55TETRAZOLYL**11OXOO1HH 66ALKOXYPYRIMID *1*22A* QUINOLINEE22CARBOXAMIDE
Document Type and Number:
Japanese Patent JPS5231098
Kind Code:
A
Abstract:
1500666 Pyrimido[1,2-a]quinoline - derived amides PFIZER Inc 14 July 1976 [1 Aug 1975] 29181/76 Heading C2C The invention comprises compounds of formula and their pharmaceutically acceptable cationic salts, wherein R 1 and R 2 are each H, Cl, F or C 1-5 alkyl or alkoxy, or R 1 -R 2 is methylenedioxy or ethylenedioxy, and R 3 is Cl, Br or C 1-5 alkoxy. In examples, the amide link is formed from 5-aminotetrazole and the analogous pyrimidoquinolinecarboxylic acid; the latter is made by hydrolysing the ethyl ester, which is in turn prepared by cyclizing a correspondingly substituted ethyl 2-quinolylaminomethylenemalonate. Additionally, the product in which R 3 is halogen may be converted to one in which R 3 is alkoxy, by reaction with an alkanol. Therapeutic compositions having antiallergy activity comprise compounds of the above formula, and may contain additional active agents such as theophylline or sympathomimetic amines.
Inventors:
SOORU BAANAADO KADEIN
Application Number:
JP8286276A
Publication Date:
March 09, 1977
Filing Date:
July 12, 1976
Export Citation:
Assignee:
PFIZER
International Classes:
A61K31/4745; A61K31/505; A61P37/08; C07D471/04; C07D491/147; (IPC1-7): A61K31/505; C07D471/04; C07D491/14