Title:
ＩＬ７受容体細胞外ドメインα鎖に対する非拮抗性抗体及び癌治療におけるそれらの使用
Document Type and Number:
Japanese Patent JP7053479
Kind Code:
B2
Abstract:
The description concerns humanized antibodies directed against the extracellular domain of the alpha chain of the receptor for interleukin-7 (IL-7), especially against the receptor for human IL-7 expressed on human cells (also designated human IL-7Ralpha or IL-7Ra or CD127) and which do not interfere with the IL-7 or TSLP signaling pathways. The antibodies described do not have an antagonistic effect on the IL-7 receptor, but may still present cytotoxic activity against CD127 positive cells. In a particular embodiment, the antibody does not have an agonist effect on the IL-7 receptor.
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Inventors:
Nicholas Poiriel
Carol Gattaz Mari
Carol Gattaz Mari
Application Number:
JP2018545380A
Publication Date:
April 12, 2022
Filing Date:
February 28, 2017
Export Citation:
Assignee:
Ose Immunotherapeutics
International Classes:
C12N15/13; A61K39/395; A61P43/00; C07K16/28; C07K19/00; C12N5/10; C12P21/08; C12Q1/02; G01N33/574
Foreign References:
| WO2013056984A1 | ||||
| WO2011094259A2 | ||||
| WO2010017468A1 |
Other References:
CHUNG B. et al.,Blood,110(8)(2007),p.2803-2810
Attorney, Agent or Firm:
Toru Ishikawa