炎症性障害の治療用の非グリコシル化/非グリコシド/非ペプチド小分子PSGL-1ミメティックス

Japanese Patent JP4686534

B2

The compounds having the general structure of formula (I) wherein the symbols, indices and substituents have the following meaningif R²=OH and R³=H then R¹=H, CN, NO₂, CF₃, F, Cl, Br, I, CH₃ orif R³=OH and R²=H then R¹=H, CN, NO₂, CF₃, F, Cl, Br, I, CH₃, Et, n-Pr, i-Pr, n-Bu, i-Bu, t-Bu, phenyl, thienyl, furyl, thiazolyl orif R³=OH and R¹=H then R²=H, CN, NO₂, CF₃, F, Cl, Br, I, CH₃, Et, n-Pr, i-Pr,n-Bu, t-Bu, phenyl, thienyl, furyl, thiazolylthen X is e.g.    with R⁴ being H, CH₃, CH₂CH₃or or    and Y being or and the pharmaceutically acceptable salts, esters or amides and prodrugs of the above identified compounds of formula (I). The compounds are applied to modulate the in-vitro and in-vivo binding processes mediated by E-, P- or L-selectin binding.

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WO/2023/180792	TOPICAL PHARMACEUTICAL COMPOSITION WITH ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY AND USES THEREOF

Kranich, Remo
Eight, Ewald Mirko

JP2007503297A

May 25, 2011

March 18, 2005

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REVOTAR BIOPHARMACEUTICALS AG

A61K31/196; A61K31/216; A61K31/341; A61K31/381; A61K31/495; A61P1/04; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P17/06; A61P19/02; A61P25/00; A61P29/00; A61P31/04; A61P37/02; A61P37/08; A61P43/00; C07C233/00; C07C235/34; C07C235/38; C07C237/00; C07C237/22; C07D207/16; C07D307/68; C07D333/24

Journal of Natural Products,1994年,57,8,1145-1151

Kuro Fukami
Toshio Morita
Yoshihei Nakamura
Yutaka Horii
Hisato Noda
Masayuki Sakai

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