Title:
非天然セマフォリン３およびそれらの医学的使用
Document Type and Number:
Japanese Patent JP6959869
Kind Code:
B2
Abstract:
The present invention relates to non-naturally occurring, mutated Semaphorin 3 molecules. Particularly, the invention relates to the mutated Semaphorin 3 or the functional fragment thereof that exhibit improved properties and pharmacologic effects, e.g., in the treatment of angiogenic disease and cancer. In addition, the present invention relates to nucleic acid molecules encoding such polypeptides, and vectors and hosts comprising such nucleic acids. The invention further relates to methods for producing the polypeptides of the invention, and to methods of using them in the treatment of disease, in particular in the medical intervention of angiogenic diseases, tumors and/or cancer.
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Inventors:
Serini, Guido
Giraud, Enrico
Tamagnone, Luka
Giraud, Enrico
Tamagnone, Luka
Application Number:
JP2017562129A
Publication Date:
November 05, 2021
Filing Date:
February 23, 2016
Export Citation:
Assignee:
Seagull Therapeutics SAS
International Classes:
C12N15/09; A61K38/17; A61K45/00; A61P3/04; A61P9/00; A61P9/10; A61P19/10; A61P25/00; A61P27/02; A61P29/00; A61P31/04; A61P35/00; A61P43/00; C07K14/705; C07K19/00; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12N15/63; C12P21/02
Domestic Patent References:
| JP9505725A |
Foreign References:
| WO2014058915A2 | ||||
| WO2011066284A1 |
Other References:
Nature, 2010年,Vol.467,p.1118-1124
Attorney, Agent or Firm:
Hiroshi Kobayashi
Norio Omori
Takayuki Imazato
Yasuhito Suzuki
Norio Omori
Takayuki Imazato
Yasuhito Suzuki