NEW MATERIAL:A 1-(3'-aminopropyl)tetrahydro-β-carboline compound shown by the formula I [R is H, 1W6C alkyl, etc.; R1 is H, 1W6C alkyl, etc.; R2 and R3 are as shown for R1, R5 CO-(R5 is 1W6C alkyl, etc.); R4 is H or 1W6C alkyl; group shown by the formula II may be group shown by the formula III (n is 1W3, m is 2 or 3; X is -CH2-, O, etc.); when R3 is R5 CO- and the sum of the alkyl carbon of R4 and R5 is 4W8, R4 and R5 may be subjected to ring closure to form group shown by the formula IV (l is 4W8)].
EXAMPLE: 1-(3'-Aminopropyl)tetrahydro-β-carboline.
USE: An intermediate for synthesizing a drug, agricultural chemical, and indole alkaloid.
PROCESS: A tryptamine compound shown by the formula V is reacted with a compound shown by the formula VI (R5 and R6 are 1W4C alkyl, etc.) in water and/or hydrophilic solvent at 60W140°C while the reaction solution being kept acidic, to give a compound shown by the formula I.
FUKUDA SHIGEO
SASAKI TAKASHI
