NEW MATERIAL:An anthracycline antibiotic substance, feudomycin B, of formula I (R1 is CH2COCH3 or CH3; R2 is group of formula II or H; when R1 is CH3, R2 is H), and feudomycin aglycone B and C.
USE: Carcinostatic agent which remarkably suppresses the proliferation of mouse leukemia cell L1210 and the synthesis of uncleic acid. It is also an intermediate which can be converted to active alycoside compound by microbial conversion or chemical conversion.
PROCESS: A mutant No. 4N-140 (FERM-P No.5520) originated from Streptomyces coeruleorubidus ME130-A4 (FERM-P No.3540) is cultured serobically in a nutrient medium for actinomycetes containing a carbon source, a nitrogen source, inorganic cimponent, and trace component, at 20W40°CC. The compound of formula III (R(3 is CH2CH3 or CH2COCH3) separated from the cultured product by convertional process is hydrolyzed with an acid to obtain the compound of formula IV (R4 is R1 or R3).
YOSHIMOTO AKIHIRO
MATSUZAWA YASUE
KOUNO KAGEAKI
INUI TAIJI
TAKEUCHI TOMIO
UMEZAWA HAMAO
