Title:
NOVEL BENZOTHIAZEPIN DERIVATIVE AND ITS PREPARATION
Document Type and Number:
Japanese Patent JPS58113185
Kind Code:
A
Abstract:
NEW MATERIAL:2-( 4-Hydroxyphenyl )-3-acetoxy-5-( 2-dimethylaminoethyl )-2,3- dihydro-1,3-benzothiazepin-4(5H)-one of formulaI, its optically active isomer, and their acid addition salts.
USE: It has coronary vessel dilating activity and is useful as a drug.
PROCESS: The compound of formulaIcan be prepared by reacting 2-(4-benzyloxyphenyl)-3-hydroxy-2,3-dihydro-1,5-benzothiazopin-4(5H)-one of formula II with dimethylaminoethyl halide, and acetylating the resultant 2-(4-benzyloxyphenyl)- 3-hydroxy-5-( 2-dimethylaminoethyl )-2,3-dihydro-1,5-benzothiazepin-4(5H)-one of formula III.
Inventors:
MAEDA SADAYUKI
UNEDA TAKASHI
SASAO YASUTAKA
TAKATANI MASAHIRO
UNEDA TAKASHI
SASAO YASUTAKA
TAKATANI MASAHIRO
Application Number:
JP21091781A
Publication Date:
July 05, 1983
Filing Date:
December 28, 1981
Export Citation:
Assignee:
HAMARI YAKUHIN KOGYO KK
International Classes:
C07D279/14; A61K31/55; A61K31/554; A61P9/08; A61P9/10; C07D279/16; C07D281/10; (IPC1-7): A61K31/55; C07D279/16
Domestic Patent References:
| JP46043785A | ||||
| JP46016749A | ||||
| JP46016988A |
Attorney, Agent or Firm:
Shoji Nakajima