新規なベンゾチエニルまたはインドール誘導体、その製造およびタンパク質プレニルトランスフェラーゼ阻害剤としてのその使用

Japanese Patent JP2004532274

A

The invention concerns compounds of general formula (1), wherein, in particular; W represents H, SO2R5. CO(CH2)nR5, (CH2)nR6, CS(CH2)nR5; X represents S or NH; Y represents (CH2)p, CO, (CH2)pCO, CH=CH-CO; Z represents a hetcrocycle, imidazole, benzimidazole, isoxazole, tetrazole, oxadiazole, thiadazole, pyridine, quinazoline, quinoxaline, quinoline, thiophene; R1 represents COOR6, CONR6R7, CO-NH-CH(R6)-COOR7, CH2NR6R7, CH2OR6, (CH2)pR6, CH=CHR6; R2 represents in particular hydrogen, C1-C10 alkyl, a substituted or unsubstituted phenyl; R5 and R6 represents hydrogen, C1-C6 alkyl; R5 represents a substituted or unsubstituted phenyl or naphthyl; R6 and R7, identical or different, represent hydrogen, C1-C15 alkyl, a hetcrocycle. an aryl; n represents 0 to 10; p represents 1 to 6.

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Michelle, Pele
Marie, Ramoto
Bridget, Hill
Chantal, Etiban

JP2003501841A

October 21, 2004

June 05, 2002

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PIERRE FABRE MEDICAMENT

C07D401/14; A61K31/138; A61K31/17; A61K31/22; A61K31/337; A61K31/366; A61K31/40; A61K31/404; A61K31/4178; A61K31/4184; A61K31/422; A61K31/427; A61K31/428; A61K31/437; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4745; A61K31/475; A61K31/496; A61K31/513; A61K31/519; A61K31/5377; A61K31/541; A61K31/573; A61K31/704; A61K31/7048; A61K31/7068; A61K33/24; A61P1/00; A61P1/16; A61P1/18; A61P5/00; A61P9/08; A61P9/10; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P29/00; A61P35/00; A61P35/02; A61P43/00; C07D403/12; C07D409/12; C07D409/14; C07D413/14; C07D521/00; (IPC1-7): C07D401/14; A61K31/138; A61K31/17; A61K31/22; A61K31/337; A61K31/366; A61K31/40; A61K31/404; A61K31/4178; A61K31/4184; A61K31/422; A61K31/427; A61K31/428; A61K31/437; A61K31/4418; A61K31/4436; A61K31/4439; A61K31/454; A61K31/4709; A61K31/4745; A61K31/475; A61K31/496; A61K31/513; A61K31/519; A61K31/5377; A61K31/541; A61K31/573; A61K31/704; A61K31/7048; A61K31/7068; A61K33/24; A61P1/00; A61P1/16; A61P1/18; A61P5/00; A61P9/08; A61P9/10; A61P11/00; A61P13/08; A61P13/10; A61P13/12; A61P15/00; A61P17/00; A61P29/00; A61P35/00; A61P35/02; C07D403/12; C07D409/12; C07D409/14; C07D413/14

Kenji Yoshitake
Yukitaka Nakamura
Konno Akio
Noritaka Yokota

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