NOVEL CARBOHYDRATE LIGAND (MYELOROLLIN) THAT CAUSES E-SELECTIN DEPENDENT CELL ROLLING AND ADHESION UNDER DYNAMIC FLOW SYSTEM

Japanese Patent JP3795588

B2

PROBLEM TO BE SOLVED: To obtain an unbranched polylactosamine that causes E-selectin dependent cell rolling and adhesion by selecting a material causing rolling from animal cells under a shear stress attainable in the human body.
SOLUTION: This unbranched polylactosamine comprises at least six monosaccharides and has terminal α2→3 sialylation and internal α1→3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue. An example of the unbranched polylactosamine is one represented by the formula (wherein R1 is α1→3 fucosylation; R2 is -OH or α1→3 fucosylation; a is 2 to 6; b is 1 to 6; and R is H, substituted or unsubstituted aryl, 1-10C alkyl, etc.). An anti-inflammatory composition can be produced by using the polylactosamine as the active ingredient.

Kazuko Handa
Mary Ellen Kay Salyan
Mark Earl Stroud
Senichirou Hakkomori

JP25077696A

July 12, 2006

August 19, 1996

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Seikagaku Corporation

C08B37/00; C12P19/26; A61K31/70; A61K31/7028; A61K31/715; A61P29/00; A61P43/00; C07H3/06; C07H15/04; C07H15/10; C12N5/07; C12N5/071; C12R1/91; (IPC1-7): C08B37/00; A61K31/70; A61K31/715; C07H15/04; //C12N5/06; C12P19/26; (C12P19/26; C12R1:91)

JP2110102A

Biochemistry,(1994),33(33),p9937-9944
Proc.Natl.Acad.Sci.USA,(1991),88,p1138-1142
J.Carbohydrate Chemistry,(1995),14(4&5),p507-523
Infection and Immunity,(1992),60(10),p4015-4023

Shisei Patent Office
Hajime Hasegawa
Kimura Hayashi
Sumiko Matsuda

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