Title:
NOVEL CHOLESTEROL METABOLITE, 5-CHOLESTEN-3β,25-DIOL DISULFATE (25HCDS) FOR THERAPY OF METABOLIC DISORDERS, HYPERLIPIDEMIA, DIABETES, FATTY LIVERS DISEASES AND ATHEROSCLEROSIS
Document Type and Number:
Japanese Patent JP2019089777
Kind Code:
A
Abstract:
To provide a compound for prevention and treatment of lipid metabolic disorders, inflammatory disorders, hyperlipidemia, diabetes, fatty liver diseases and atherosclerosis.SOLUTION: The compound is 5-cholesten-3,25-diol disulfate (25HCDS) represented by the formula in the figure, or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: Figure 1
Inventors:
REN SHUNLIN
Application Number:
JP2019002297A
Publication Date:
June 13, 2019
Filing Date:
January 10, 2019
Export Citation:
Assignee:
UNIV VIRGINIA COMMONWEALTH
International Classes:
C07J31/00; A61K9/08; A61K9/14; A61K9/19; A61K9/20; A61K9/48; A61K31/575; A61K47/02; A61P1/16; A61P3/06; A61P3/10; A61P9/10; A61P29/00
Domestic Patent References:
| JP6125610B2 | 2017-05-10 |
Foreign References:
| WO2006047022A1 | 2006-05-04 |
Other References:
BAI, Q ET AL.: "Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory elem", METABOLISM, vol. 61, JPN6016044009, 2012, pages 836 - 845, ISSN: 0004387078
BAI, Q ET AL.: "Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signal", ATHEROSCLEROSIS, vol. 214, JPN6016044010, 2011, pages 350 - 356, ISSN: 0004387079
REN, S ET AL.: "Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, JPN6016044011, 2007, pages 802 - 808, XP025990001, ISSN: 0004387080, DOI: 10.1016/j.bbrc.2007.06.143
BAI, Q ET AL.: "Sulfation of 25-hydroxycholesterol by SULT2B1b decreases cellular lipids via the LXR/SREBP-1c signal", ATHEROSCLEROSIS, vol. 214, JPN6016044010, 2011, pages 350 - 356, ISSN: 0004387079
REN, S ET AL.: "Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 360, JPN6016044011, 2007, pages 802 - 808, XP025990001, ISSN: 0004387080, DOI: 10.1016/j.bbrc.2007.06.143
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta
Satoshi Fujita
Natsuo Tanaka
Naoko Kikuta