Title:
NOVEL COMPOUND HAVING LYSINE-SPECIFIC DEMETHYLATING ENZYME 1 INHIBITORY ACTIVITY, METHOD FOR PRODUCING THE SAME, AND USE OF THE SAME
Document Type and Number:
Japanese Patent JP2020152641
Kind Code:
A
Abstract:
To provide a novel compound having high lysine-specific demethylating enzyme (LSD) 1 inhibitory activity, high selectivity for LSD1 inhibition, and/or useful therapeutic effects on various diseases.SOLUTION: The present invention relates to a compound represented by formula (I), a stereoisomer thereof, a salt of them, or a solvate of them. [In the formula, L is a single bond, alkylene, or the like; and A is a substituted/unsubstituted cycloalkyl, substituted/unsubstituted heterocycle, or the like.]SELECTED DRAWING: None
Inventors:
UMEHARA TAKASHI
SATO KOKORO
KOYAMA HIROO
YAMAMOTO HIROBUMI
KONDO YUTAKA
KATSUSHIMA KEISUKE
FURUKAWA YUSUKE
KIKUCHI JIRO
SATO KOKORO
KOYAMA HIROO
YAMAMOTO HIROBUMI
KONDO YUTAKA
KATSUSHIMA KEISUKE
FURUKAWA YUSUKE
KIKUCHI JIRO
Application Number:
JP2017134173A
Publication Date:
September 24, 2020
Filing Date:
July 07, 2017
Export Citation:
Assignee:
INSTITUTE PHYSICAL & CHEMICAL RES
UNIV NAGOYA CITY
UNIV JICHI MEDICAL
UNIV NAGOYA CITY
UNIV JICHI MEDICAL
International Classes:
C07C217/74; A61K31/132; A61K31/337; A61K31/40; A61K31/407; A61K31/437; A61K31/438; A61K31/472; A61K31/495; A61K31/497; A61K31/4985; A61K31/4995; A61P35/00; A61P35/02; A61P43/00; C07C213/08; C07D205/04; C07D207/14; C07D211/26; C07D211/56; C07D211/58; C07D211/62; C07D213/72; C07D217/06; C07D241/20; C07D295/185; C07D295/192; C07D295/215; C07D305/06; C07D401/04; C07D487/04; C07D487/08; C07D487/10; C07D491/107
Attorney, Agent or Firm:
Hiraki International Patent Office