NEW MATERIAL: An indan derivative of formula I [A is C=X (X is O, S); Y is N, N+-O--, CR8; R1, R2 are H, alkyl, or put together to be polymethylene; R3 is H, OH, alkoxy, acyloxy; R4 is H or put together with R3 to be single bond; when A is C=X, R5 is H, alkyl, alkenyl, aryl, etc.; R6 is H, alkyl, when A is single bond, R5, R6 form five to seven-membered unsaturated heterocyacle with bonded N; R7, R8 are H, alkyl, OH, NO2, CN, etc.; P is 0, 1].
EXAMPLE: Cis-1,1-dimetyl-50-nitro-3-(2-oxopyrrolidin-1-yl)indan-2-ol.
USE: Having smooth muscle relaxation activity and useful for curing the diseases of respiratory tract and cardiovascular tract.
PROCESS: For example, a compound of formula II is reacted with a compound of formula III to obtain a compound of formula I in which P is O and A is C=X.
AIBAN REO PINTO
KORIN MAIKERU ETSUJI
