Title:
新規化合物及び甲状腺ホルモン受容体アゴニストとしてのそれらの使用
Document Type and Number:
Japanese Patent JP7445996
Kind Code:
B2
Abstract:
A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto. (I), (Ia)
Inventors:
Jumbo, Chang
Qi, Xiaoshin
Qi, Xiaoshin
Application Number:
JP2021549443A
Publication Date:
March 08, 2024
Filing Date:
February 20, 2020
Export Citation:
Assignee:
NANJING RUIJIE PHARMA CO., LTD.
International Classes:
C07D253/075; A61K31/18; A61K31/42; A61K31/444; A61K31/53; A61K31/675; A61P1/16; A61P3/04; A61P3/06; A61P3/10; A61P5/18; A61P9/00; A61P9/10; A61P35/00; A61P43/00; C07C311/53; C07D261/12; C07D401/10; C07D403/12; C07D413/12; C07D471/04; C07F9/6558
Domestic Patent References:
| JP2012106996A | ||||
| JP2009501759A | ||||
| JP2010539209A | ||||
| JP2001114768A | ||||
| JP2009500305A | ||||
| JP2022504706A |
Foreign References:
| WO2018075650A1 | ||||
| WO2007128492A1 | ||||
| WO2007134864A1 |
Other References:
Hormone and Metabolic Research ,2011年,Vol.43, No.11,p737-742,doi:10.1055/s-0031-1291177
Journal of Medicinal Chemistry,2014年,Vol.57, No.10,p3912-3923,doi:10.1021/jm4019299
長瀬 博,最新創薬化学 上巻 ,株式会社テクノミック,1998年08月15日,p248-253,ISBN 4-924746-59-2
Journal of Medicinal Chemistry,2014年,Vol.57, No.10,p3912-3923,doi:10.1021/jm4019299
長瀬 博,最新創薬化学 上巻 ,株式会社テクノミック,1998年08月15日,p248-253,ISBN 4-924746-59-2
Attorney, Agent or Firm:
Katsumi Iseki
Shuhei Kaneko
Shuhei Kaneko