Title:
NOVEL CRYSTAL OF PIPERACILLIN SODIUM
Document Type and Number:
Japanese Patent JP2007246514
Kind Code:
A
Abstract:
To provide a novel crystal of piperaccillin sodium having a pharmaceutically excellent effect, and a preparation for use in powder-filled injection filled with the same.
A novel crystal of piperacillin sodium having a diffraction angle of 6.1, 10.2, 12.4, 15.1, 15.8 and 18.6° and a novel crystal of piperacillin sodium having a diffraction angle of 5.3, 6.1, 8.7, 10.2, 12.4 and 18.6° expressed as the value 2θ in a powder X-ray diffraction pattern have excellent solubility and low hygroscopicity, have a small electrification property, and are extremely easy to handle with when producing a drug substance and when filled to be a preparation, and a preparation filled with the same is useful.
COPYRIGHT: (C)2007,JPO&INPIT
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Inventors:
MORI MASARU
NISHIKAWA MASARU
NISHIKAWA MASARU
Application Number:
JP2007032211A
Publication Date:
September 27, 2007
Filing Date:
February 13, 2007
Export Citation:
Assignee:
TOYAMA CHEMICAL CO LTD
International Classes:
C07D499/68; A61K31/431; A61P31/04
Domestic Patent References:
| JPH03506025A | 1991-12-26 | |||
| JP2004514694A | 2004-05-20 | |||
| JPS5123284A | 1976-02-24 | |||
| JPH01135787A | 1989-05-29 | |||
| JPS62103089A | 1987-05-13 |
Foreign References:
| US20030028016A1 | 2003-02-06 |
Other References:
仲井由宣ほか編, 新製剤学, vol. 第１版, JPN6011023129, 25 November 1982 (1982-11-25), pages 102 - 103, ISSN: 0002340722