Title:
NOVEL CRYSTALLINE CEPHADOLOXYL AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS63267789
Kind Code:
A
Abstract:
The invention relates to a novel crystalline cefadroxyl hemihydrate having a K.F. between about 3.5 and 2.0% : such compound is more stable than other cefadroxyl molecules. The novel cefadroxyl is obtained preparing and isolating a novel cefadroxil solvate of dimethylacetamide, or of N-methyl-2--pyrrolidone or of monomethylformamide, slurrying said solvate with a mixture methanol/isopropyl alcohol 30:70 to 70:30 by volume in the presence of from 5% to 12% of water a temperature of about +45 DEG C to + 55 DEG C and then filtering the so obtained compound.
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Inventors:
MARSILI LEONARDO (IT)
Application Number:
JP2267088A
Publication Date:
November 04, 1988
Filing Date:
February 02, 1988
Export Citation:
Assignee:
RIFAR SRL (IT)
International Classes:
A61K31/545; C07D501/00; C07D501/04; C07D501/12; C07D501/22; C07D; (IPC1-7): C07D501/00; C07D501/22
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)