To provide a novel cyclic squaric acid amide derivative or a salt thereof, and a prophylactic and/or therapeutic agent comprising at least one thereof as an active ingredient, which is particularly used for diseases against which a calcium antagonist is effective.
The compound represented by formula (1) (wherein A represents an aromatic hydrocarbon ring or aromatic heterocycle (with the ring and the heterocycle being optionally substituted); X1 and X2 may be the same or different and each represents oxygen atom, sulfur atom or NR3; Y represents CO, CS, CNR4, -CR5R6-, -CR5R6CR7R8- or -CR5R6CR7R8CR9R10-; Z represents a chalcogen atom or NR11; R1, R2, R3, R4, R5, R6, R7, R8, R9, R10 and R11 may be the same or different and each represents a hydrogen atom, halogen atom, hydroxyl group, mercapto group, amino group or organic group optionally substituted; R1 and R2 may be united to form a hydrocarbon ring or heterocycle (with the ring and the heterocycle may be optically substituted); one of R5, R6, R7, R8, R9and R10 together with R3 may form optionally substituted heterocycle; and the broken line represents single bond or double bond.) or a salt thereof is provided.
SETOGUCHI HIROKO
MOGI HIROYUKI
TSUJI FUMIO
AONO HIROYUKI
BAN MASAKAZU
