Title:
NOVEL CYCLOPROPYLMETHYLPIPERAZINES AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS57131772
Kind Code:
A
Abstract:
A compound having the formula in which R is hydrogen or alkyl having 1 to 4 carbon atoms; R1 is hydrogen, alkyl having 1 to 5 carbon atoms, cycloalkylmethyl in which the cycloalkyl group has from 3 to 6 carbon atoms, 2-hydroxyethyl, alkoxycarbonyl in which the alkoxy group has 1 or 2 carbon atoms, 2-carboxypropyl, N-benzyl-2-carbamoyl propyl, phenyl, phenyl substituted by methoxy, trifluoromethyl or acetyl, benzyl, benzyl substituted by halogen, benzoyl, benzoyl substituted by three methoxy groups, 3,5-dimethoxy-4-acetoxy or 3,5-dimethoxy-4-ethoxycarbonyloxy, cinnamoyl, cinnamoyl in which the phenyl ring is substituted with trifluoromethyl or by one or more methoxy groups, phenoxyacetyl, phenoxyacetyl in which the phenyl ring is substituted with halogen or methoxy, and in which m is 2 or 3 and R2 and R3 are identical and are alkyls having 1 to 3 carbon atoms; A is a pharmaceutically acceptable compound selected from the group consisting of inorganic acids, organic acids, alkyl halides and aryl halides; and n is 0, 1, 2 or 3; The compounds are useful in the treatment of cardiac disease symptomized by low cardiac flow.
Inventors:
FUERUNANTO MATSUKUSU ROBA
MISHIERU OOROOSOU
MISHIERU OOROOSOU
Application Number:
JP16003681A
Publication Date:
August 14, 1982
Filing Date:
October 07, 1981
Export Citation:
Assignee:
INNOTHERA LAB SA
International Classes:
C07D295/02; A61K31/495; A61K31/535; A61K31/5375; A61K31/55; A61P9/00; A61P9/04; A61P9/08; A61P9/10; C07D241/04; C07D295/03; C07D295/06; C07D295/073; C07D295/08; C07D295/088; C07D295/096; C07D295/10; C07D295/112; C07D295/12; C07D295/14; C07D295/15; C07D295/18; C07D295/185; C07D295/192; C07D295/20; C07D295/205; C07D317/68; C07D409/06; (IPC1-7): A61K31/495; A61K31/535; A61K31/55; C07D241/04; C07D295/02; C07D295/06; C07D295/08; C07D295/12; C07D295/14; C07D317/68; C07D409/04