NOVEL DAUNOBICINE DERIVATIVE * PRODUCTION THEREOF AND USE OF SAME AS DRUG

Title:

NOVEL DAUNOBICINE DERIVATIVE * PRODUCTION THEREOF AND USE OF SAME AS DRUG

Document Type and Number:

Japanese Patent JPS5419959

Kind Code:

A

Abstract:

Daunorubicin derivs. of formula (I) and their acid addition salts are new: (R = H or 1-2C alkyl). They are made by reacting 14-bromodaunorubicin (II) with a quat. ammonium phosphate. (I) are low toxicity antitumour agents particularly for treating lymphoblastic and myeloblastic actue leukaemia and solid tumours. The daily adult dose is 1-5 mg/kg intravenously. -

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Inventors:

JIYANNBERUNAARU DEYUSE
DANIERU FUARUJIYU
JIERAARU BONSHINE
DANIERU REISUDORUFU

Application Number:

JP8312378A

Publication Date:

February 15, 1979

Filing Date:

July 10, 1978

Export Citation:

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Assignee:

RHONE POULENC SA

International Classes:

A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; A61P35/00; C07H15/252; (IPC1-7): A61K31/70; C07H15/24

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