NOVEL DERIVATIVE OF INDOLECARBOXYAMIDE, SALT OF SAME, MANUFACTURE, USE AS INTERMEDIATE AND DRUG AND COMPOSITION CONTAINING SAME

Title:

NOVEL DERIVATIVE OF INDOLECARBOXYAMIDE, SALT OF SAME, MANUFACTURE, USE AS INTERMEDIATE AND DRUG AND COMPOSITION CONTAINING SAME

Document Type and Number:

Japanese Patent JPS6216460

Kind Code:

A

Abstract:

Novel indole-carboxamides of the formula I wherein R and R1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, -CF3, CH3S-, -NH2 and -NO2 or R1 and R taken together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a member of the group consisting of -O-, -S- and R' is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, phenyl, naphthyl, aralkyl of 7 to 12 carbon atoms and substituted phenyl, R3 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkoxy of 1 to 3 carbon atoms, chlorine, bromine, iodine, -NO2, -NH2, acylamide of an aliphatic carboxylic acid of 2 to 5 carbon atoms and mono and dialkylamino with alkyl of 1 to 5 carbon atoms, a and b form =O and c is hydrogen or a and c form a carbon-carbon bond and b is hydrogen, A is selected from the group consisting of -(CH2)n-and n is an integer from 2 to 5, m is an integer from 1 to 3, B is R2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anti-arrhythmic properties.

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Inventors:

FURANSOWA KUREMANSU
JIYATSUKU GIYOOMU
JIRU AMON

Application Number:

JP15989986A

Publication Date:

January 24, 1987

Filing Date:

July 09, 1986

Export Citation:

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Assignee:

ROUSSEL UCLAF

International Classes:

A61K31/40; A61K31/403; A61K31/404; A61K31/445; A61K31/495; A61P9/06; C07D209/08; C07D209/34; (IPC1-7): A61K31/40; A61K31/445; C07D209/08; C07D209/34

Attorney, Agent or Firm:

Motohiro Kurauchi

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