NEW MATERIAL: N-Acyl-N,N'-di-lysoganglioside, N'-acyl-N,N'-di-lysoganglioside, N,N'-diacyl-N,N'-di-lysoganglioside, their esters, amides, peracylated derivatives and salts, wherein the acyl groups are derived from an unsubstd. 1-24C aliphatic acid or 2-24C aliphatic acid substd. by a polar group such as Cl, etc.

EXAMPLE: N-Dichloroacetyl-N'-acetyl-N,N'-di-lysoganglioside.

USE: Natural ganglioside substitutes useful for treatment of nervous system disorders.

PROCESS: N,N'-Di-lysoganglioside is acylated by the reaction with an acid derivative such as methyl chloroacetate, etc., in the presence of a base such as triethylamine, etc.