NEW MATERIAL: A compd. represented by formula I (wherein a wavy line means an E- or Z-isomer; R1 and R are each H, a protective group or combined together to form a protective group; R3 and R5 are each H, alkyl, alkenyl, cycloalkyl or aryl; R4 is H or alkyl or R4 and R5 are combined to form alkylene; and alkylene, R3, R4 and R5 may be substd. by alkyl, OH, CN, NO2, NH2 or halogen) and its acid derivative.
EXAMPLE: 2-Fluoro-5-t-hexyldimethylsilyloxy-2(Z)-pentenoic acid ethyl.
USE: A starting substance of the production of modified oligo and polypeptide being dipeptidemimetic (false dipeptide) and having advantageous various characteristics.
PROCESS: A compd. represented by formula II or a hydroxymethyl group of corresponding aldehyde is oxidized and carboxylic acid obtained according to circumstances is converted to its acid deriv.
ERUNSUTO HANGERUBIYUURERU
RENE RATSUTOMAN
SHIRUBUIO OFUNERU
WARUTAA SHIIRINGU
GEORUGU UON SUPURETSUHIYAA
EDOWARUDO FUERUDERU
