NEW MATERIAL:An isothiourea derivative of formula I (R is hydroxy group or chlorine).
EXAMPLE: N-Cyano-N'-(2-chloroethyl)-S-methyl isothiourea.
USE: Useful as an intermediate for the preparation of cimetidine which blocks histamine H2-receptor and has the remedying activity to gastric ulcer, duodenal ulcer, etc. The compound can be prepared from aminoethanol and chloroethylamine which are easily available in the market, and accordingly it has excellent industrial value.
PROCESS: The compound of formula I is prepared by reacting an ethylamine derivative of formula II with dimethylcyanoimide dithiocarbonate of formula III in a polar solvent at a temperature between room temperature and 110°C for 0.5W5 hours. The polar solvent is selected from those which do not directly concern with the reaction, e.g. alcohols.
| JP2005508841 | Compounds and methods |
| JPS51114206 | INCREASING METHOD FOR TIELD RATIO OF RICE CULTIVATION |
FUNAZUKURI GIICHI
SHIGEARI TOSHIMITSU
SEKI KOUICHI
