NOVEL L-THREO-ADRENALIC ACID - MICROBIAL CHEM RES FOUND

Title:

NOVEL L-THREO-ADRENALIC ACID

Document Type and Number:

Japanese Patent JPS59112949

Kind Code:

A

Abstract:

NEW MATERIAL:L-Threo-3-(3,4-dihydroxyphenyl)-N-methylserine, its salt and their hydrate.

USE: Useful as a remedy for Perkinson's disease and an antidepressant. It forms adrenaline by the decarbonation in the peripheral system or in the brain, and exhibits various actions to the nervous system.

PROCESS: The titled compound can be prepared by (1) optically resolving recemic threo-3-(3,4-dibenzyloxyphenyl)-N-p-methoxybenzyloxycarbonyl-serine with optically active ephedrin, optically active 2-amino-1,1-diphenyl-1-propanol, etc., (2) removing the protecting group with an acid, (3) subjecting the product to N-methylation reaction, and (4) further removing the protecting group.

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Inventors:

UMEZAWA HAMAO
NAGATSU TOSHIHARU
NARABAYASHI HIROTAROU
TAKEUCHI TOMIO
IWADARE SHIYUUICHI
MATSUMOTO IKUO
YOSHIZAWA JIYUNJI
MORISHIMA HAJIME
TOMIMOTO KOUJI

Application Number:

JP22179782A

Publication Date:

June 29, 1984

Filing Date:

December 20, 1982

Export Citation:

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Assignee:

MICROBIAL CHEM RES FOUND

International Classes:

A61K31/195; A61P25/00; C07C229/36; A61P25/24; A61P25/26; C07B57/00; (IPC1-7): A61K31/195; C07C101/40

Domestic Patent References:

JPH027306A

1990-01-11

Attorney, Agent or Firm:

Shigeru Yagida

Previous Patent: JPS59112948

Next Patent: CYCLOALKENYL DERIVATIVES, MANUFACTURE AND USE