Title:
NOVEL MANUFACTURE OF 20-KETO-DELTA 16-STEROID AND NOVEL INTERMEDIATE COMPOUND OBTAINED THEREBY
Document Type and Number:
Japanese Patent JPS59206398
Kind Code:
A
Abstract:
The invention relates to a new process for the introduction into steroids of a 17-side chain containing a 20-keto group under the simultaneous formation of an unsaturated bond between C16 and C17 by reaction of 17-(isocyano-sulfonylmethylene)-steroids with an alkylating agent to 20-isocyano-20-sulfonyl-delta<1><6>-steroids, followed by hydrolysis of these latter compounds to 20-keto-delta<1><6>-steroids. The invention also relates to the intermediate compounds which are formed in this process, i.e. 20-isocyano-20-sulfonyl-delta<1><6>-steroids and to the ultimately formed 20-keto-delta<1><6>-steroids, as far as these latter compounds are new.
Inventors:
ARUBERUTO MATEEOSU FUAN REEOSE
ADORIAAN MARINUSU FUAN REEOSEN
ADORIAAN MARINUSU FUAN REEOSEN
Application Number:
JP8602184A
Publication Date:
November 22, 1984
Filing Date:
April 27, 1984
Export Citation:
Assignee:
GIST BROCADES NV
International Classes:
C07B61/00; C07J13/00; B01J31/02; C07J41/00; C07J75/00; (IPC1-7): C07J13/00; C07J41/00
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)