NOVEL OLIGONUCLEOTIDE CONJUGATES AND USE THEREOF

Japanese Patent JP2016216468

A

PROBLEM TO BE SOLVED: To provide a double stranded oligo-RNA structure in which target-specific ligands are bonded to the double stranded oligo-RNA structure which binds by covalent bond high molecular compounds for improving the delivery of double stranded oligo-RNA that can be valuably used in treating diseases, specifically, cancer, and production methods thereof; and to provide a target-specific double stranded oligo-RNA delivery technology through the structure.SOLUTION: The present invention provides a therapeutic agent-polymer structure to which a ligand having a structure represented by formula (1) is bounded (A is a hydrophilic substance; B is a hydrophobic substance; X and Y are each independently a simple covalent bond or a linker-mediated covalent bond; R is a therapeutic drug; L is a ligand having a binding property specific to a receptor which promotes target cell internalization by receptor mediated endocytosis). In the therapeutic agent-polymer structure to which the ligand is bounded, the therapeutic drug is a double-stranded oligo RNA, or an anti-cancer agent.SELECTED DRAWING: Figure 1

CHAE JEIWOOK
HAN BO RAM
KIM HAN-NA
PARK HAN OH
YOON PYOUNG OH
KIM SUNG-GI
JUNG KWANG-JU
KWON TAEWOO
CHOI JONG DEOK
JUNG EUN-JUNG
LEE SAM YOUNG

JP2016115635A

December 22, 2016

June 09, 2016

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BIONIA CORP

A61K47/48; A61K9/14; A61K31/7105; A61K31/713; A61K39/395; A61K47/06; A61K47/10; A61K47/12; A61K47/14; A61K47/18; A61K47/22; A61K47/24; A61K47/26; A61K47/28; A61K47/32; A61K47/34; A61K47/42; A61K48/00; A61P31/00; A61P35/00; C12N15/113

JP2011522070A

2011-07-28

WO2010131916A2	2010-11-18
WO2010042823A1	2010-04-15

Kenichi Morita
Kenjiro Yamaguchi
Hironori Nagayama
Yuzaki Ozaki

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