NOVEL OPTICALLY ACTIVE CARBOXYLIC ACID DERIVATIVE L-LYSINE SALT AND ITS PREPARATION

Title:

NOVEL OPTICALLY ACTIVE CARBOXYLIC ACID DERIVATIVE L-LYSINE SALT AND ITS PREPARATION

Document Type and Number:

Japanese Patent JPS6322556

Kind Code:

A

Abstract:

NEW MATERIAL:L-Lysine salt of d-threo-2-hydroxyl-3-(2-aminophenylthio)-3-(4- methoxyphenyl-)-propionic acid of formula I (*C means the carbon of the molecule which has been optically resolved).

USE: A synthetic intermediate of medicines. It is used as a synthetic intermediate of diltiazem hydrochloride, a remedy for angina pectoris and essential hypertension.

PREPARATION: dl-threo-2-Hydroxyl-3-(2-aminophenylthio )3-( 4-methoxyphenyl )-propionic acid of formula II and L-lysine or a salt of the propionic acid and L-lysine salt are allowed to react in a solvent such as methanol whereby the corresponding salt is obtained. Two kinds of the optically active diastereomers formed are separated by utilizing the difference in solubility between them and the compound of formula I is obtained as a hard soluble component.

Inventors:

NAKAMOTO YASUMASA
ISHIZUKA YORIYASU
FUTSUKAICHI OSAMU

Application Number:

JP16471586A

Publication Date:

January 30, 1988

Filing Date:

July 15, 1986

Export Citation:

Click for automatic bibliography generation Help

Assignee:

NIHON IYAKUHIN KOGYO CO LTD
SANYO KAGAKU KENKYUSHO KK

International Classes:

C07B57/00; C07B31/00; C07C67/00; C07C229/26; C07C313/00; C07C323/56; C07D281/10; (IPC1-7): C07B57/00; C07C101/24; C07C148/00; C07C149/273; C07D281/10

Foreign References:

US4533748A

1985-08-06

Attorney, Agent or Firm:

Heiyoshi Odashima

Previous Patent: A detecting device and a display with a detection function

Next Patent: JPS6322557