Title:
NOVEL PEPTIDES AND COMBINATIONS OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST EPITHELIAL OVARIAN CANCER AND OTHER CANCERS
Document Type and Number:
Japanese Patent JP2020198875
Kind Code:
A
Abstract:
To provide peptides for use in cancer immunotherapy, nucleic acids encoding the peptides, T lymphocytes activated ty the peptides, antibodies that recognize the peptides, kits and pharmaceutical compositions containing the same, and methods for producing personalized anticancer vaccines using the peptides.SOLUTION: The invention provides: a peptide comprising an amino acid sequence which is at least 88% homologous to a peptide sequence derived from HLA class I and HLA class II molecules of a human tumor cell, where the peptide binds to a major histocompatibility complex (MHC) molecule and is recognized by CD4 and/or CD8T cells, and not a full-length polypeptide; a nucleic acid encoding the peptide; an activated T lymphocyte activated by the peptide; an antibody that recognizes the peptide. The invention also provides kits and pharmaceutical compositions for use in the diagnosis and/or treatment of cancer comprising the peptide, the nucleic acid, the T lymphocyte or the antibody, and methods for producing personalized cancer vaccines using the peptides.SELECTED DRAWING: None
Inventors:
HEIKO SCHUSTER
JANET PEPER
PHILIPP WAGNER
HANS-GEORG RAMMENSEE
JANET PEPER
PHILIPP WAGNER
HANS-GEORG RAMMENSEE
Application Number:
JP2020082964A
Publication Date:
December 17, 2020
Filing Date:
May 11, 2020
Export Citation:
Assignee:
IMMATICS BIOTECHNOLOGIES GMBH
International Classes:
C12N15/12; A61K35/15; A61K35/17; A61K38/08; A61K38/10; A61K39/00; A61K39/395; A61K48/00; A61P35/00; A61P35/02; A61P43/00; C07K11/00; C07K14/435; C07K14/725; C07K16/18; C12N5/0783; C12N5/0784; C12N5/10; C12N15/115; C12N15/63; C12Q1/6874; G01N33/15; G01N33/50; G01N33/53; G01N33/574
Foreign References:
| WO2014157692A1 | 2014-10-02 |
Other References:
LEUKEMIA, vol. Vol.20, p.2025-2033, JPN6021022025, 2006, ISSN: 0004525522
Attorney, Agent or Firm:
Takashi Shoji