To provide a pharmaceutical dosage form comprising a controlled release component comprising an antihyperglycemic drug in combination with a second component comprising a thiazolidinedione derivative.
A pharmaceutical dosage form comprises: a compressed tablet core comprising at least one pharmaceutically acceptable excipient and metformin hydrochloride; an osmotic tablet comprising a sustained release membrane surrounding the compressed tablet core, with which the metformin hydrochloride is released from the osmotic tablet so that the peak plasma level of the metformin is obtained between 6-12 hours after administration after meal; and an immediate release layer surrounding the sustained release membrane of the osmotic tablet, containing pioglitazone hydrochloride and a low-viscosity water-soluble binder, hydroxypropyl cellulose, that has a viscosity between 2 and 6 mPa.S when tested as a 2% aqueous solution at 20°C.
NANGIA AVINASH
LODIN UNCHALEE
CARDINAL JACK R
TAKEDA CHEMICAL INDUSTRIES LTD
| JP2002326927A | 2002-11-15 | |||
| JP2003514011A | 2003-04-15 |
| WO2004026241A2 | 2004-04-01 | |||
| WO2002060448A1 | 2002-08-08 | |||
| US20040161462A1 | 2004-08-19 |
HANDBOOK OF PHARAMACEUTICAL EXCIPIENTS, vol. Fourth Edition, JPN6013051014, 2003, pages 289 - 293, ISSN: 0002852858
Takuji Harada
Takanori Mamoru
Taiji Morikawa
Amamiya Yasuhito
Kei Sakurada
Mie Hideki
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