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Title:
NOVEL PHYSIOLOGICALLY ACTIVE COMPOUND KS-506 AND PRODUCTION THEREOF
Document Type and Number:
Japanese Patent JPH021463
Kind Code:
A
Abstract:

NEW MATERIAL:A compound expressed by the formula [X and Y are single bond or -C(=O)-].

USE: Useful as medicines, such as bronchodilator, cardiotonic agent, vasodilator, hormone secretion promoter or antiallergic agent.

PREPARATION: A microorganism, e.g., Mortierella.vinacea KAC-1436 (FERM P-1776), belonging to the genus Mortierella and having the ability to produce KS-506 compound is cultured in a culture medium to produce and accumulate the KS-506 compound in the culture and collect the KS-506 compound expressed by the formula from the above-mentioned culture. The culture is carried out at 15-30°C temperature and about a neutral pH using glucose, fructose, stabilose, etc., as a carbon source, and NH4Cl, ammonium sulfate, etc., as a nitrogen source and inorganic substances by a shaking, spinner culture method with aeration, etc.


Inventors:
KURODA KAZUTOSHI
KASE HIROSHI
ANDO KATSUHIKO
KAWAMOTO ISAO
YASUZAWA TORU
SANO HIROSHI
Application Number:
JP21604488A
Publication Date:
January 05, 1990
Filing Date:
August 30, 1988
Export Citation:
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Assignee:
KYOWA HAKKO KOGYO KK
International Classes:
C12P11/00; A61K31/235; A61K31/60; A61P7/02; A61P9/04; A61P11/08; A61P43/00; C07C323/20; C07C381/00; C12R1/645; (IPC1-7): A61K31/235; A61K31/60; C07C323/20; C07C381/00; C12P11/00