Title:
エンドリシン活性を有する新規ポリペプチド及びその使用
Document Type and Number:
Japanese Patent JP2011504366
Kind Code:
A
Abstract:
The present invention provides isolated polypeptides comprising the amino acid sequence of SEQ ID NO: 1, or a fragment, variant, derivative or fusion thereof which is capable of binding specifically to and/or lysing cells of Clostridium difficile, and means for producing the same, with the proviso that the fragment, variant, derivative or fusion is not a naturally occurring lysin of a bacteriophage of Clostridium difficile. The invention further provides methods for killing bacterial cells, such as cells of Clostridium difficile, and for diagnosing, treating and preventing diseases and conditions associated with infection of the same. The invention also provides diagnostic kits for use in such methods.
Inventors:
Michael gassson
Melinda Meier
Aryan Narbad
Melinda Meier
Aryan Narbad
Application Number:
JP2010534544A
Publication Date:
February 10, 2011
Filing Date:
November 24, 2008
Export Citation:
Assignee:
Plant Bioscience Limited
International Classes:
C12N15/09; A61K9/52; A61K35/74; A61K35/76; A61K38/00; A61K48/00; A61P31/04; C07K14/005; C12N1/21; C12P21/02; C12Q1/02; C12Q1/68
Domestic Patent References:
| JP2005516618A | 2005-06-09 |
Other References:
JPN6013023605; Ｂｏｒｙｓｏｗｓｋｉ Ｊ ｅｔ ａｌ: Ｅｘｐｅｒｉｍｅｎｔａｌ Ｂｉｏｌｏｇｙ ａｎｄ Ｍｅｄｉｃｉｎｅ Ｖｏｌ．２３１, 2006, ｐ．２６６-３７７
JPN6013023603; Ｇｏｈ ｅｔ ａｌ: Ｍｉｃｒｏｂｉｏｌｏｇｙ Ｖｏｌ．１５３, 2007, ｐ．６７６-６８５（２００７）
JPN6013023603; Ｇｏｈ ｅｔ ａｌ: Ｍｉｃｒｏｂｉｏｌｏｇｙ Ｖｏｌ．１５３, 2007, ｐ．６７６-６８５（２００７）
Attorney, Agent or Firm:
Junji Yuda
Noriyuki Takebayashi
Noriyuki Takebayashi