Title:
NOVEL PTERIDINE DERIVATIVES, MANUFACTURE AND MEDICINAL COMPOSITION
Document Type and Number:
Japanese Patent JPS61140585
Kind Code:
A
Abstract:
Pteridines of the formula in which R2 denotes the piperazino or N-formylpiperazino group, R4 denotes a dialkylamino, phenylalkylamino, N-alkylphenylalkylamino, pyrrolidino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino, thiazolidino or 1-oxidothiazolidino group, R6 denotes a hydrogen atom or an alkyl or phenyl group and R7 denotes an alkylamino group, dialkylamino, phenylalkylamino, N-alkylphenylalkylamino, piperidino, morpholino, thiomorpholino, 1-oxidothiomorpholino or piperazino group, where in the radicals R4, R6 and R7 each alkyl moiety can in each case contain 1 to 3 carbon atoms and at the same time one or both alkyl groups having 2 or 3 carbon atoms of the radicals R4 and R7 can be substituted in the 2- or 3- position in each case by a hydroxyl group, and their acid addition salts. These, if R2 represents the N-formylpiperazino group, are useful intermediates for the preparation of the pteridines of the formula I in which R2 represents the piperazino group, which have useful pharmacological properties, in particular antithrombotic action, metastases-inhibiting action and an inhibitory action on tumour growth. The novel compounds can be prepared by processes known per se.
Inventors:
YOZEFU ROTSUHO
ARUMIN HETSUKERU
YOZEFU NITSUKURU
ERITSUHI MIYUURAA
BERUTORUDO NAARU
REINAA JINMAAMAN
HANSU BUAIZENBAAGAA
ARUMIN HETSUKERU
YOZEFU NITSUKURU
ERITSUHI MIYUURAA
BERUTORUDO NAARU
REINAA JINMAAMAN
HANSU BUAIZENBAAGAA
Application Number:
JP27885985A
Publication Date:
June 27, 1986
Filing Date:
December 11, 1985
Export Citation:
Assignee:
THOMAE GMBH DR K
International Classes:
A61K31/505; A61K31/519; A61P7/02; A61P35/00; C07D475/06; C07D475/08; (IPC1-7): A61K31/505; C07D475/06; C07D475/08
Attorney, Agent or Firm:
Hideto Asamura