NEW MATERIAL:The tannin of formula I (l and n are integer of 0W6; m is 0 or 1; l+m+n=6; R1 is H or G; G is group of formula II; 3 G groups are present in one molecule; there is no bond between 4-site and 4-site; the black point represents the bonding site; X is group of formula IIIWIV; R2 is group of formula VWVII).
USE: Antipsychotic agent useful for the remedy of acute schizophrenia and chronic schizophrenia.
PREPARATION: DAIO (rhizome of Pheum palmatum) is extracted with water or an aqueous solution of a water-soluble organic solvent, and the extract or its concentrate is subjected to the gel-filtration chromatography, and eluted successively with water, an aqueous solution of ethanol, ethanol, and methanol to obtain a methanol fraction. After optional concentration, the fraction is subjected to gel-filtration chromatography, and then eluted with a mixture of two or more solvents selected from methanol, ethanol, water and acetone. The eluate is subjected to high-performance liquid chromatography under specific condition, and a fraction eluted at a retention time of 10W25 min is collected. The objective compound of formula I is obtained by distilling out the solvent form the eluate.
NONAKA GENICHIRO
FUJIWARA MICHIHIRO
UEKI AKIKAZU
| JPS58154571A | 1983-09-14 |