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Title:
NOVEL THIAZOLE DERIVATIVE
Document Type and Number:
Japanese Patent JPS62132871
Kind Code:
A
Abstract:

NEW MATERIAL:A thiazole derivative expressed by formula I (R1 is H, hydroxyalkyl, hydroxyiminoalkyl, alkoxyiminoalkyl, formyl, carboxy, cyano, nitro, halogen, thiocayanate or formula III; R2 is H, alkyl, alkanoyl or alkoxycarbonyl; A1 is alkylene; R3 and R4 are H or alkyl or R3 and R4 together form pyrrolidine ring, piperidine ring, morpholine ring or piperazine ring, provided that R2 is alkanoyl or alkoxycarbonyl when R1 is H) or a salt thereof.

EXAMPLE: 4-(3,5-Di-tert-butyl-4-hydroxyphenyl)-5-formyl-2(3H)-thiazolone.

USE: An anti-inflammatory agent, antipyretic agent, analgesic agent, antiarthritic agent, antirheumatic agent and immunological function regulator.

PREPARATION: For example, a compound expressed by formula II is subjected to the Vilsmeier reaction to afford the aimed formyl compound expressed by formula Ia.


Inventors:
ISOMURA YASUO
ABE TETSUSHI
Application Number:
JP27275285A
Publication Date:
June 16, 1987
Filing Date:
December 03, 1985
Export Citation:
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Assignee:
YAMANOUCHI PHARMA CO LTD
International Classes:
C07D277/20; A61K31/425; A61K31/426; A61P25/04; A61P29/00; A61P37/00; C07D277/34; C07D277/56; C07D277/58; (IPC1-7): A61K31/425; C07D277/34; C07D277/56; C07D277/58
Attorney, Agent or Firm:
Shozo Nagai (1 person outside)