Title:
トランスフォーミング成長因子(TGF)阻害剤としての新規トリアゾールおよびオキサゾール化合物
Document Type and Number:
Japanese Patent JP4518956
Kind Code:
B2
Abstract:
Novel oxazole and thiazole compounds, including derivatives thereof, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use are described. The compounds of the present invention are potent inhibitors of transforming growth factor ("TGF")-beta signaling pathway. They are useful in the treatment of various TGF-related disease states including, for example, cancer and fibrotic diseases.
Inventors:
Bramberg, Laura Cook
Munchov, Michael John
Munchov, Michael John
Application Number:
JP2004568899A
Publication Date:
August 04, 2010
Filing Date:
September 08, 2003
Export Citation:
Assignee:
Pfizer Products Inc.
International Classes:
C07D413/14; A61K31/4439; A61K31/444; A61K31/4709; A61K31/498; A61P1/16; A61P3/10; A61P9/10; A61P11/00; A61P13/12; A61P17/00; A61P17/02; A61P35/00; A61P43/00; C07D413/04; C07D417/04; C07D417/14; C07D419/14; C07D471/04; C07D487/04
Foreign References:
| WO2002062776A1 | ||||
| WO2002062793A1 | ||||
| WO2002062753A1 | ||||
| WO2000061576A1 |
Attorney, Agent or Firm:
Yoshinobu Murofushi
High Hoji Koji
Junko Miyazawa
Noh four
High Hoji Koji
Junko Miyazawa
Noh four