NOVEL TRIFLATE AND PRODUCTION OF OXYGEN-CONTAINING COMPOUND USING THE SAME

Title:

NOVEL TRIFLATE AND PRODUCTION OF OXYGEN-CONTAINING COMPOUND USING THE SAME

Document Type and Number:

Japanese Patent JPH02223576

Kind Code:

A

Abstract:

NEW MATERIAL:A triflate expressed by the formula (R and R' are cyclic or acyclic alkyl; n is 1 or 2).

USE: Capable of readily synthesizing various optically active substances or cyclic ether compounds and extremely useful for producing the basic skeleton of natural compounds having physiological activity.

PREPARATION: A solution of anhydrous trifluoromethanesulfonic acid in anhydrous methylene chloride is dripped into the objective alcohol-anhydrous methylene chloride-pyridine solution at about -15°C in nitrogen atmosphere to afford the compound expressed by the formula. The above-mentioned triflate is used to provide an oxygen-containing compound by triflating alcohols having an oxygen functional group at the β-position and reacting the resultant compound with an organocopper reagent or reacting the alcohols with a Grignard reagent in the presence of a copper compound catalyst.

Inventors:

KOTSUKIBI KICHIZOU
KADOTA ISAO
USHIO YASUYUKI
OCHI MASAMITSU

Application Number:

JP4564789A

Publication Date:

September 05, 1990

Filing Date:

February 27, 1989

Export Citation:

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Assignee:

CENTRAL GLASS CO LTD

International Classes:

C07D317/12; C07D307/06; C07D307/12; C07D309/06; C07D313/00; C07D313/04; C07D313/18; C07D317/24; C07D325/00; C07H7/02; (IPC1-7): C07D307/06; C07D307/12; C07D309/06; C07D313/00; C07D313/04; C07D313/18; C07D317/12; C07D317/24; C07D325/00; C07H7/02

Attorney, Agent or Firm:

Eiichi Sakamoto

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