Title:
Nrf2-RELATED GENE EXPRESSION PROMOTER
Document Type and Number:
Japanese Patent JP2016199501
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide an Nrf2 gene expression promoter and a GCLM gene expression promoter comprising a novel component as an active ingredient.SOLUTION: The technical characteristics of the invention for solving the problem are: (1) an Nrf2 gene expression promoter comprising Dianthus plants and/or extract thereof as an active ingredient; and (2) a GCLM gene expression promoter comprising Dianthus plants and/or extract thereof as an active ingredient.SELECTED DRAWING: None
Inventors:
NAGAI HIROKI
OKABE SHIGENAO
TANAKA JUNJI
MURAI HIROMICHI
OKABE SHIGENAO
TANAKA JUNJI
MURAI HIROMICHI
Application Number:
JP2015080891A
Publication Date:
December 01, 2016
Filing Date:
April 10, 2015
Export Citation:
Assignee:
ORIZA YUKA KK
International Classes:
A61K36/36; A61K8/97; A61P1/16; A61P3/10; A61P9/00; A61P9/10; A61P35/00; A61P43/00; A61Q19/02
Other References:
KIM SJ ET AL.: "Tyrosinase Inhibitory Activity of Plant Extracts (III): Fifty Korean Indigenous Plants", THE JOURNAL OF APPLIED PHARMACOLOGY, vol. 11, no. 4, JPN6019000806, 2003, pages 245 - 248, XP053020246, ISSN: 0003958077
SHIN IS ET AL.: "Dianthus superbus fructus suppresses airway inflammation by downregulating of inducible nitric oxide", JOURNAL OF INFLAMMATION, vol. 9, no. 1, JPN6019000807, 2012, pages 41, XP021136417, ISSN: 0003958078, DOI: 10.1186/1476-9255-9-41
伊東 健: "Nrf2酸化ストレス応答系による病態制御", 生化学, vol. 第８１巻，第６号, JPN6019000809, 2009, pages 447 - 455, ISSN: 0003958079
LIN W, ET AL.: "Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 depend", BIOCHEMICAL PHARMACOLOGY, vol. 76, no. 8, JPN6019000811, 2008, pages 967 - 973, XP025478962, ISSN: 0003958080, DOI: 10.1016/j.bcp.2008.07.036
KIM SJ ET AL.: "Tyrosinase Inhibitory Activity of 80 Plant Extracts (II)", THE JOURNAL OF APPLIED PHARMACOLOGY, vol. 11, no. 1, JPN6019000812, 2003, pages 5 - 7, XP053020242, ISSN: 0003958081
LUO JG ET AL.: "Three new triterpenoid saponins from Dianthus superbus", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 59, no. 4, JPN6019000813, 2011, pages 518 - 521, ISSN: 0003958082
SHIN IS ET AL.: "Dianthus superbus fructus suppresses airway inflammation by downregulating of inducible nitric oxide", JOURNAL OF INFLAMMATION, vol. 9, no. 1, JPN6019000807, 2012, pages 41, XP021136417, ISSN: 0003958078, DOI: 10.1186/1476-9255-9-41
伊東 健: "Nrf2酸化ストレス応答系による病態制御", 生化学, vol. 第８１巻，第６号, JPN6019000809, 2009, pages 447 - 455, ISSN: 0003958079
LIN W, ET AL.: "Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 depend", BIOCHEMICAL PHARMACOLOGY, vol. 76, no. 8, JPN6019000811, 2008, pages 967 - 973, XP025478962, ISSN: 0003958080, DOI: 10.1016/j.bcp.2008.07.036
KIM SJ ET AL.: "Tyrosinase Inhibitory Activity of 80 Plant Extracts (II)", THE JOURNAL OF APPLIED PHARMACOLOGY, vol. 11, no. 1, JPN6019000812, 2003, pages 5 - 7, XP053020242, ISSN: 0003958081
LUO JG ET AL.: "Three new triterpenoid saponins from Dianthus superbus", CHEMICAL AND PHARMACEUTICAL BULLETIN, vol. 59, no. 4, JPN6019000813, 2011, pages 518 - 521, ISSN: 0003958082