Title:
NUCLEIC ACID MONOMERS
Document Type and Number:
Japanese Patent JP2022053148
Kind Code:
A
Abstract:
To provide techniques for reducing stability of formed polynucleotide double strands.SOLUTION: The disclosed method comprises introducing into a polynucleotide at least one kind of nucleoside unit selected from a group consisting of: nucleoside unit 1 in which a group of a formula (1): -NH-C(=O)-R1 (in the formula, R1 is a hydrogen atom or an alkyl group) is linked to 2' carbon atom of a sugar: nucleoside unit 2 in which the amino group in cytosine is replaced by a hydrocarbon group; and a nucleoside unit 3 in which a group of a formula 3: -(O-CH2-)n-(S-)m-R4 (in the formula: R4 is a hydrocarbon group, n and m are respectively an integer of 1-3) is linked to 2' carbon atom of a sugar.SELECTED DRAWING: None
Inventors:
ABE HIROSHI
ABE NAHOKO
KIMURA YASUAKI
NOMURA KOHEI
TEI KUMIKO
KOBAYASHI YOSHIAKI
AHN SEONG-JIN
ABE NAHOKO
KIMURA YASUAKI
NOMURA KOHEI
TEI KUMIKO
KOBAYASHI YOSHIAKI
AHN SEONG-JIN
Application Number:
JP2020159793A
Publication Date:
April 05, 2022
Filing Date:
September 24, 2020
Export Citation:
Assignee:
TOKAI NATIONAL HIGHER EDUCATION & RES SYSTEM
UNIV TOKYO
UNIV TOKYO
International Classes:
C07H19/10; A61K31/713; A61K48/00; A61P43/00; C12N15/113
Attorney, Agent or Firm:
Patent Business Corporation Saegusa International Patent Office