Title:
核酸の輸送
Document Type and Number:
Japanese Patent JP3763577
Kind Code:
B2
Abstract:
PCT No. PCT/AU95/00505 Sec. 371 Date Apr. 16, 1997 Sec. 102(e) Date Apr. 16, 1997 PCT Filed Aug. 16, 1995 PCT Pub. No. WO96/05218 PCT Pub. Date Feb. 22, 1996The present invention provides a method for introducing nucleic acids into cells. The method involves exposing the cells to a compound having formula (1), in which w is a nucleic acid, x is a peptide or amino acid, y is a linker having a chain length equivalent to 1 to 20 carbon atoms or is absent, R4 is H ir CH2O-R3; and R1, R2 and R3 are the same or different and are either hydrogen, methyl, ethyl, hydroxyl or an acyl group derived from a fatty acid having a carbon chain of 3 to 24 carbon atoms saturated or unsaturated, with the proviso that at least one of R1, R2 and R3 is an acyl group derived from a fatty acid, or to a compound having the formula (2): w . . . xyNHCH2CH2OR5, in which w is a nucleic acid, x is a peptide or amino acid, y is a linker having a chain length equivalent to 1 to 20 carbon atoms or absent, R5 is an acyl group derived from a fatty acid having a carbon chain of 3 to 24 carbon atoms saturated or unsaturated. The invention also relates to these compounds.
Inventors:
Fittaker, robert
Cameron, Fiona Helen
Vendor, veronica
Mogadam, Minu
Jennings, Philip Anthony
Cameron, Fiona Helen
Vendor, veronica
Mogadam, Minu
Jennings, Philip Anthony
Application Number:
JP50686596A
Publication Date:
April 05, 2006
Filing Date:
August 16, 1995
Export Citation:
Assignee:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION
International Classes:
C07H21/02; A61K9/127; C12N15/09; A61K47/48; A61K48/00; C07H21/00; C07H21/04; C07K2/00; C07K5/068; C07K5/09; C07K5/11; C07K7/06; C07K7/08; C07K14/00; C12N15/87; C12N15/88; C07K
Domestic Patent References:
| JP9501655A |
Foreign References:
| WO1991009837A1 |
Other References:
Pept.Res.,Vol.6,No.3(1993)p.125-128
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Shigeo Naruse
Takashi Watanabe
Shigeo Naruse