Title:
抗原発現を駆動する哺乳動物CD80/CD86遺伝子プロモーターを有する核酸ワクチン組成物
Document Type and Number:
Japanese Patent JP2004522403
Kind Code:
A
Abstract:
Polynucleotides encoding at least one immunizing antigen whose expression is controlled by a promoter derived from a gene encoding a co-stimulatory molecule are provided. The polynucleotides may also encode adjuvants. Compositions comprising at least one immunizing agent and at least one cytokine that enhance dendritic cell stimulation and/or survival are also provided. Methods for eliciting an immune response against the immunizing agent are also provided. The method includes the steps of administering the polynucleotides and, optionally, co-administering an adjuvant.
Inventors:
Umrah, Scott
Roberts, Lee Kay.
Roberts, Lee Kay.
Application Number:
JP2001534408A
Publication Date:
July 29, 2004
Filing Date:
November 01, 2000
Export Citation:
Assignee:
Powderject Vaxins, Incorporated
International Classes:
C12N15/09; A61K9/14; A61K38/00; A61K39/00; A61K39/21; A61K39/29; A61K47/02; A61K48/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/04; A61P37/08; A61P43/00; C07K14/475; C07K14/705; (IPC1-7): C12N15/09; A61K9/14; A61K38/00; A61K39/00; A61K39/29; A61K47/02; A61K48/00; A61P31/00; A61P31/04; A61P31/10; A61P31/12; A61P35/00; A61P37/08; A61P43/00
Foreign References:
| WO1998028332A2 | 1998-07-02 | |||
| WO1998046083A1 | 1998-10-22 | |||
| WO1996014855A1 | 1996-05-23 |
Attorney, Agent or Firm:
Takeshi Oshio