Title:
エナンチオ選択的なエナミドのカルボニル基への求核付加反応方法と光学活性α-ヒドロキシ-γ-ケト酸エステル、ヒドロキシジケトンの合成方法
Document Type and Number:
Japanese Patent JP4822844
Kind Code:
B2
Abstract:
A method of an enantioselective nucleophilic addition reaction to carbonyl, which enables an asymmetric synthesis of an optically active ±-hydroxy-³-keto acid ester, an optically active ±-hydroxy-³-amino acid ester, hydroxydiketone compounds, etc. being useful as a raw material or synthesis intermediate for producing a pharmaceutical preparation, an agricultural chemical, a fragrance, a functional polymer or the like. In this method, the nucleophilic addition reaction of enamide compound accompanied by hydroxyl (-OH) formation to carbonyl is carried out in the presence of a chiral catalyst with copper or nickel.
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Inventors:
Osamu Kobayashi
Application Number:
JP2005517333A
Publication Date:
November 24, 2011
Filing Date:
January 24, 2005
Export Citation:
Assignee:
Japan Science and Technology Agency
International Classes:
C07C69/716; C07C67/333; C07C67/343; C07C269/00; C07C269/04; C07C271/22; C07D207/18; C07D207/273; C07D307/33; C07B53/00; C07B61/00
Domestic Patent References:
| JP2003260366A | 2003-09-16 | |||
| JP2003260363A | 2003-09-16 |
Attorney, Agent or Firm:
Toshio Nishizawa