Title:
オキシム連結のための求核触媒
Document Type and Number:
Japanese Patent JP7304402
Kind Code:
B2
Abstract:
The Invention relates to materials and methods of conjugating a water soluble polymer to an oxidized carbohydrate moiety of a therapeutic protein comprising contracting the oxidized carbohydrate moiety with an activated water soluble polymer under conditions that allow conjugation. More specifically, the present invention relates to the aforementioned materials and methods wherein the water soluble polymer contains an active aminooxy group and wherein an oxime or hydrazone linkage is formed between the oxidized carbohydrate moiety and the active aminooxy group on the water soluble polymer, and wherein the conjugation is carried out in the presence of a nucleophilic catalyst.
Inventors:
Jurgen Siegman
Stephan Haida
Hanspeter Lottensteiner
Peter Thulesec
Stephan Haida
Hanspeter Lottensteiner
Peter Thulesec
Application Number:
JP2021215385A
Publication Date:
July 06, 2023
Filing Date:
December 29, 2021
Export Citation:
Assignee:
Takeda GmbH
International Classes:
A61K38/36; A61K47/61; A61K38/37; A61P7/04; A61P43/00; C07K1/113; C07K1/18; C07K1/20; C07K1/22; C07K1/34; C07K14/745; C07K14/755
Foreign References:
| WO2012016131A1 |
Attorney, Agent or Firm:
Shusaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
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