Title:
RNA依存性RNAウイルス感染を治療するためのヌクレオシドアリールホスホルアミデート
Document Type and Number:
Japanese Patent JP2009526850
Kind Code:
A
Abstract:
The present invention provides nucleoside aryl phosphoramidates of structural formula (I) which are precursors to inhibitors of RNA-dependent RNA viral polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors of hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside aryl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside aryl phosphoramidates of the present invention.
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Inventors:
Matsukos, Malcolm
Olsen, David Bee
Dongi, monica
Gardeturi, Christina
Harper, Stephen
Martet
Narueshi, Frank
Pacini, Barbara
Olsen, David Bee
Dongi, monica
Gardeturi, Christina
Harper, Stephen
Martet
Narueshi, Frank
Pacini, Barbara
Application Number:
JP2008555315A
Publication Date:
July 23, 2009
Filing Date:
February 12, 2007
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07H19/10; A61K31/7068; A61P31/14
Attorney, Agent or Firm:
Yoshio Kawaguchi
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura
Makoto Ono
Chihiro Watanabe
Kenkyo Kanayama
Katsuma Osaki
Mitsuaki Tsubokura