Title:
RNA依存性RNAウィルスポリメラーゼ阻害薬としてのヌクレオシド誘導体
Document Type and Number:
Japanese Patent JP2004532184
Kind Code:
A
Abstract:
The present invention provides nucleoside derivatives (principally uracil, cytosine and uridine derivatives) which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside derivatives alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside derivatives of the present invention.
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Inventors:
Carroll, Stephen S
Rough Emina, Robert El
Hall, Dawn El
Himelberger, Amy El
Kuo, Lawrence Sea
Matsukos, Malcolm
Olsen, David Bee
Rutkowski, Carrier A
Tomasini, Giyoan Yi
Anne, Hao Yun
Bart, Barcelien
Nirima, Burt
Cook, Philip Dan
Eldratop, Anne Bee
Ginotsuso, Challes Jei
Purhaftsue, Mary
Placasille, Tarza Pea
Rough Emina, Robert El
Hall, Dawn El
Himelberger, Amy El
Kuo, Lawrence Sea
Matsukos, Malcolm
Olsen, David Bee
Rutkowski, Carrier A
Tomasini, Giyoan Yi
Anne, Hao Yun
Bart, Barcelien
Nirima, Burt
Cook, Philip Dan
Eldratop, Anne Bee
Ginotsuso, Challes Jei
Purhaftsue, Mary
Placasille, Tarza Pea
Application Number:
JP2002558479A
Publication Date:
October 21, 2004
Filing Date:
January 18, 2002
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
Isis PharmaceuticalsInc
Isis PharmaceuticalsInc
International Classes:
A61K31/519; A61K31/70; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7076; A61K31/708; A61K31/7105; A61K31/712; A61K38/21; A61K45/00; A61K45/06; A61P1/16; A61P31/14; A61P43/00; C07D473/00; C07D487/02; C07H19/00; C07H19/04; C07D487/04; C07H19/048; C07H19/06; C07H19/067; C07H19/09; C07H19/10; C07H19/14; C07H19/16; C07H19/167; C07H19/173; C07H19/19; C07H19/20; C07H; C12N; (IPC1-7): A61K31/519; A61K31/7064; A61K31/7068; A61K31/708; A61K45/00; A61P31/14; A61P43/00; C07D487/04; C07H19/10; C07H19/20
Domestic Patent References:
| JP2004520367A | 2004-07-08 |
Foreign References:
| US6110901A | 2000-08-29 | |||
| WO1998055493A1 | 1998-12-10 | |||
| WO1998011121A1 | 1998-03-19 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura