NUCLEUS SUBSTITUTED 22HYDROXYPHENYLMETHANE SULFAMIC ACID

Title:

NUCLEUS SUBSTITUTED 22HYDROXYPHENYLMETHANE SULFAMIC ACID

Document Type and Number:

Japanese Patent JPS5481239

Kind Code:

A

Abstract:

Nuclear substituted 2-hydroxyphenylmethane-sulfamic acids and their pharmaceutically acceptable salts wherein the phenyl nucleus is substituted with 2 to 4 nuclear substituents and which are useful saluretic-diuretics and anti-inflammatories are disclosed. The products may be prepared by reacting nuclear substituted salicylaldehydes with ammonium sulfamate to generate intermediate imines which are reduced to afford the compounds of this invention.

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Inventors:

ROBAATO ERU SUMISU
JIERARUDO II SUTOTSUKAA
EDOWAADO JIEE KURAGOO JIYUNIYA

Application Number:

JP14348978A

Publication Date:

June 28, 1979

Filing Date:

November 22, 1978

Export Citation:

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Assignee:

MERCK & CO INC

International Classes:

A61K31/18; A61P7/10; A61P9/12; A61K31/19; A61P29/00; C07C45/56; C07C67/00; C07C301/00; C07C307/02; C07C313/00; C07C323/49; (IPC1-7): A61K31/18; C07C143/86; C07C149/425

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