PURPOSE: To obtain an ointment in the mouth having excellent adhesion for many hours by blending an oily base with a compound capable of forming a complex thereof with a polyacrylic acid or a salt thereof.
CONSTITUTION: An oily base is blended with a compound capable of forming a complex thereof with a polyacrylic acid or a salt thereof, namely one or more of chitosan, polyvinyl pyrrolidone and polyvalent metallic salt and optionally an excipient, a surfactant, a solubilizer, etc., and pharmaceutically manufactured to give the objective substance. The objective substance contains 1-30% polyacrylic acid, 1-40% chitosan, 1-40% polyvinyl pyrrolidone or 0.01-30% polyvalent metallic salt. By the formation of the complex, the ointment itself is made into an insolubilized film, which can prevent elimination of the base, make a sustained release of drug and the objective substance can be administered without feeling of physical disorder like an ointment in the mouth molded into tablets or a lamellar state.
OKADA TAIZO
MORIOKA SHIGEO
| JP2013036233A | 2013-02-21 | |||
| JP2012087495A | 2012-05-10 | |||
| JPH08199874A | 1996-08-06 | |||
| JP2013189843A | 2013-09-26 |